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Company Research Projects

A list of companies and technologies that have been selected for research projects include:

Curcumin Derivative
Stony Brook University

Researchers at Stony Brook University have found a therapeutic use for extracts from certain Indian spices. The extract has been shown to treat certain diseases and skin irritations, but until now was unusable due to its extreme insolubility and toxic effects on cells. The TCRC report provided to the Stony Brook researchers detailed applications of the modified extract, outlined the steps necessary for FDA approval and implications therein, discussed what IP protection is best suited for the invention, listed potential funding sources, and provided several exit strategies ranging from strategic partnership to sale or licensing of the technology and who the best options would be.

Micro Environment Heating System (MEHS)

Binghamton University

The MEHS was developed by researchers at Binghamton University in an effort to increase worker productivity and reduce energy costs through highly targeted personal heating. Developed through integration of existing technologies, the TCRC report provided Binghamton with information about the necessary steps to FDA approval during the prototyping stage, listed the best markets available for the MEHS, discussed the IP landscape for inventions similar to the MEHS, detailed considerations to be weighed if the MEHS were commercialized, and covered the central business decisions Binghamton would need to make regarding bringing the MEHS to market through several different options.

Smart Window

DIMIEN LLC aimed to capitalize on the growing trend towards green building by creating a window capable of automatically transitioning from based on the ambient air temperature and without requiring any electrical input. Additionally, DIMIEN’s windows blocked only IR light (heat) while letting in visible light. The TCRC report for DIMIEN laid out the current state of the smart window market, identified DIMIEN’s primary competitive advantages over currently available and lab stage smart windows, provided an understanding of the entire glass market as well as listed the segments to enter first, outlined the options DIMIEN has for commercialization, detailed various funding options including state/national/private, provided an overview of the various state regulatory standards diMien would need to comply with, and recommended an IP strategy for DIMIEN to follow regardless of their path to commercialization.

Custodial Suicide Prevention System
Zinnia Safety Systems, LLC

Zinnia Safety Systems LLC has developed an innovative new way to monitor patients at risk for suicide in custodial care settings. The TCLP addressed the intellectual property rights of the product that was developed by employees of SUNY Upstate Medical University. Although not yet patented, any patent on the device will be owned by Upstate but Zinnia Safety Systems LLC will be exclusive licensee of any patent issued. The report summarized relevant research and other data on suicide prevention, specifically focusing on custodial settings in New York State. The report reviews the major technological components of the device as well as the historical developments of the technologies incorporated in the device. An overview of competitive markets that included substitute and competitive technologies already in use was provided. Finally the report reviews the potential liability and regulatory issues the system faces if implemented in custodial settings. An analysis and recommendations for potential commercialization were also included

PatDek Claims Analysis Software
Lithosphere Software LLC

Lithosphere Software LLC developed software to facilitate requirements for challenging or defending a patent. The TCLP looked at the technology and provided an overview of the current status of the market. They examined common reasons the legal profession is reluctant to adopt new technology as well as a potential method for valuing Lithosphere’s product. They did a cursory search of potentially relevant intellectual property and created potential market strategy for expanding the reach of the software. There were several specific questions that Lithosphere had posed to the TCLP, which were researched and answered. The report also suggested changes that could be made to improve the performance and marketability of the software. Potential partners were highlighted for consideration in marketing the product and a market strategy for expansion was recommended.

Advanced Fetal Monitoring
Advanced Fetal Monitoring LLC

Advanced Fetal Monitoring LLC (AFM LLC) has developed an advanced fetal monitoring system. The TCLP dissected the proposed technologies and compared them to technologies on the market. The current manufacturers of fetal monitors were studied and data was provided on their total sales dollars and market share. The potential market for AFM LLC’s product was determined and an in-depth analysis of the potential market size for the technology’s specific advantage was provided.
The competitive technologies compared to the potential market were evaluated and suggestions were provided for how to bring the product to market. These suggestions included explanation of available funding as well as strategies for partnering with existing manufacturers. A timeline was created from inception all the way to manufacturing and marketing to explain the increasing value throughout the various stages of development. The final portion of the report laid out a strategy for the intellectual property issues surrounding the product and a three-step plan was suggested.

Liquid Natural Gas Fuel Tanks

This report examined the potential business strategies for the introduction of the technology developed by Hebeler and another company, CFS. The report outlined the technology, and assessed other competitive technologies in the market. A discussion of the intellectual property issues surrounding the tank reviewed the company patents and other patents in the LNG tank industry. IP protection strategies were explored. An overview of the trucking market and fuel prices as well as a competitive analysis of the LNG tank market was provided. Three business models were considered: an educational and technology assistance (ETA) model, a traditional licensing agreement model, and a manufacturing model, where tanks would be manufactured in-house.

High Quality, High Performance Fibers
Free Form Fibers

Commercialization strategies for Free Form Fibers (FFF)’s process to manufacture high-quality, high-performance fibers were examined in this project. An overview of the technology and the technologies competing with the FFF process such as fiber spinning and traditional chemical vapor deposition was provided. (In addition to this being essential for the understanding of the researchers, it enables the report to be understood by the lay reader including potential investors.)
A market section examined the various applications of three of the materials utilized by FFF, and focused on two in three markets in which the FFF technology could be competitive: gas turbines, cutting tools, and armor. The report identified competing firms within the pinpointed markets and discussed potential business models that FFF could employ in entering those markets.
Regulatory concerns specific to the high performance fiber market were analyzed as well as potential export regulations facing technologies in the FFF process field. Intellectual property issues such as patent law, assignment of patent rights and curing inventorship were discussed.

Thermoelectric Cooling
Ephesus Technologies, LLC

The Ephesus Technologies’ advanced thermoelectric (“TE”) cooling technology project considered commercialization strategies and relevant legal issues for the Ephesus IP. A comprehensive analysis of the competitive commercialization environment for TE technology, including market trends, competitors, and challenges of entry was completed. Industry analyses for the semiconductor, micro machine, nanotechnology and TE industries were provided along with classification codes used by potential market competitors and start-up partners as well as detailed profiles for main U.S. players in the TE industry. Legal issues attendant to licensing university technology were explored, including a review of issues that may arise from various sponsored research agreements and including implications of federal or non-governmental third party funding. Intellectual property rights of various potential partner entities involved in the funding, research, development and commercialization of the RCTE technology were also examined.

Radio Frequency Modules 

Anaren designs and manufacturers low-power radio frequency modules capable of being integrated into lighting equipment for wireless lighting systems. The research report analyzed the wireless lighting controls market with particular reference to the opportunities and barriers to entry that a module manufacturer is likely to face. The technology being utilized in the low power RF field relating to wireless lighting was analyzed, as well as competing technologies and potential technological markets for Anaren. A representative number of market participants were profiled demonstrating a flooded and fragmented market.

Intellectual property relevant to Anaren’s technology and RF lighting modules was provided, and the major intellectual property owner in the market identified and profiled as an aggressive litigator against competitors infringing its patents. Institutional research and development in wireless lighting was reviewed, an overview of the applicable regulations provided and the technological, market, and intellectual property factors affecting Anaren’s business strategy analyzed. A series of recommendations to enter the wireless lighting market were offered; including focusing on core competency of integration, value added solution and university research partnerships. 

Medical Image Analysis Software
Imagination Software 

Imagination Software Corporation (ISC) developed medical image analysis software to help dental clinicians understand and interpret image data. Image analysis software can process and analyze both two-dimensional (2-D) and three-dimensional (3-D) images to provide information that cannot be obtained through visual observation alone. The report examined ISC’s technology, assessed competitive technologies on the market, and provided an overview of the dental market and a competitive analysis of it. Alternative markets where ISC technology would be applicable were reported on. Sales and distribution methods for the technology, and options for advertising the software were discussed. Regulatory matters pertaining to the technology such as FDA regulations and the necessary procedures to obtain market clearance for the dental imaging software were analyzed. The duration and complexity of the regulatory approval process was noted for consideration in developing a commercialization strategy.

Intellectual property principals relevant to ISC’s technology, including patents, copyrights, trademarks and trade secrets were reviewed, and recommendations for ISC’s market entry were made to maximize ISC’s competitive advantages such as price, size, portability, ease of use, minimal radiation dose, and procedural efficiency. 

Diffinity Genomics: DNA Extraction 
Diffinity Genomics Inc.

Diffinity Genomics, Inc. specializes on the analysis of nucleic acid (NA). In Q1 2010, Diffinity began marketing a product that purifies NA samples. Purification implies removing all of the unwanted materials from a sample, thus leaving only the desired material. Diffinity’s process is reportedly faster, uses fewer reagents, and requires a smaller number of steps than the competition. The next development of the company is to extend their technology into the extraction of NA from samples. 

The report provided a discussion of specific markets in which Diffinity may have a significant competitive advantage with its extraction technology, and the intellectual property. A comparative analysis of Diffinity’s competitive advantage and a recommendation concerning the best method(s) of market entry in order to maximize its probability of success was provided. 

Molecular Transistor device 

Qutronics is an R&D firm specializing in cutting-edge nanoscale electronic components. It owns a patent for a method of connecting three electrodes to a molecule. The technology is competitively advantageous in several ways—in power consumption, heat dissipation, unit price, speed, and fabrication costs for static random access memory (“SRAM”) applications. These advantages are valuable in battery-operated devices and personal computers as well as servers and mainframe computers. Qutronics has a patent application for a method of creating the nanometer-sized gap that is necessary to build a molecular sensor. Qutronics’ method of creating the nanometer-sized gap, combined with Qutronics’ expertise in the field of molecular electronics, will provide a competitive advantage in creating a molecular-based DRAM memory chip and a molecular-based handheld explosive detection device.

The report discussed competing technologies and potential applications for Qutronics’ technology. It reviewed all aspects of the explosives detection market, including market share, size, trend and growth information, and offered a competitive analysis of the security sensor markets, including barriers to market entry, market pressures, and current market participants. A list of competitive patents was provided along with a brief description of trademark and trade secret protection. The report concluded with a brief analysis of existing technologies and a discussion of niche application markets. 

Super-Critical Biodiesel Fuel
Syracuse University Supercritical Fuel Technology Laboratory

The method of biodiesel production that utilizes a base catalytic method presents several problems, including unmarketable waste products, long production times and significant cost. Supercritical Manufactured Biodiesel (“SMB”) seeks to cut biodiesel production cost by allowing for an array of inputs while substantially reducing production time and waste products.

The research report analyzed issues relating to the supercritical method created by Profession George Anitescu and Professor Lawrence L. Tavlarides of Syracuse University. It included a market section listing pertinent characteristics and trends that currently shape the biodiesel industry; a government regulations section addressing what role the government is playing in the growth of the new industry; an intellectual property section reviewing several other technologies similar to SMB; and a recommendation about the most practical business structure for bringing SMB technology to market. 

Data Visualization Systems 
C Speed 


C Speed is a product development and engineering services company. Its programmers engineered a new way to look at complex data sets, highlight relationships between seemingly unrelated data types, and allow a data user to customize the display to meet specific needs; all in the form of a data visualization system (DVS). The report provided a comprehensive view of the developing technology and its commercialization potential. A detailed description of the visualization system, its competitive environment, relevant markets, intellectual property considerations, and regulatory matters was provided. The technology portion of the report provides a brief description of the resolution C Speed offers to combat the apparent problems in complex data visualization. In addition, an evaluation of different markets including testing & measurement, medical, and defense was provided. The testing and measurement industry both in the United States and throughout the world is dominated by a few firms, three of which are profiled in the market section. The legal section discusses the various types of intellectual property protection available and the applications to which each type most directly applies. An analysis of these topics and recommendations for potential applications was also included.

ScrubiT Pro
This report focused on a technology developed by JP Morgan Chase to clean documents of metadata. If a document is sent outside of a firm without first cleaning it of metadata, it can reveal confidential information about the document and the firm. The report provided an overview of metadata technology and the dangers it can present. Various existing metadata cleaning programs were explored in this project and then compared to reveal the benefits and weaknesses of each individual package.   Commercialization paths available to the client were explored as well as other potential opportunities for the information technology. These opportunities included the financial service market. This market consists of such institutions as hedge funds, retail brokerages firms, sell-side firms, private client groups, traditional asset managers, and full-service firms. The accounting market was considered because accounting firms use some of the most difficult and complicated information technology systems to manage and integrate their business. The law firm market was another potential market for ScrubIT! Pro since information technology is increasingly intertwined in the practice of law. Another option explored was selling ScrubIT! Pro to an information technology service or product provider. A sale would assist in reaching customers in the financial services, accounting, and law firm markets, allowing the client to commercialize the technology while avoiding the cost of additional development, manufacturing, marketing, and distribution of its technology.

Assessing the Success of Technology Transfer Offices
Over the past ten years, a number of research studies have found various factors to be associated with the success of university technology transfer offices (TTOs). The objective of this research project was to test the degree of correlation between the past effectiveness factors and hypothesized effectiveness factors on the success of TTOs as measured by three sets of data collected by the Association of University Technology Managers (AUTM). To test this degree of correlation, and the success of TTOs, three sets of AUTM data were used to measure TTO success: (1) the ratio of licensing revenue to research expenditures; (2) the ratio of number of licenses and options to research expenditures; and (3) the ratio of the number of startup companies to research expenditures. The score for each TTO on each of the three ratio measures of success was calculated. A composite list of TTOs ranging from the most successful to the least successful was developed and analyzed to determine which factors correlated most significantly with TTO success. The report concluded that the composite efficiency score is a reliable means to assess overall success in technology transfer, and that business expertise at the TTO and state support for technology commercialization are probably important factors contributing to the success of TTOs. 

Ecovative Design, LLC

Ecovative Design, LLC developed a new method for creating a sturdy biodegradable material with potential to be developed in a number of useful ways. Examples include structural cores, green packaging, and bioplastics. The report discussed protecting further innovation through patent protection and maintaining innovations as trade secrets, both with regard to employees and dealings with third parties. The report provided a representative summary of some United States and foreign patents classified in technical fields relating to Ecovative’s technology to illustrate fields in which technologies of potential interest are currently used. Relevant regulations and standards that affect Ecovative’s products were evaluated. These include ASTM International (originally American Society for Testing and Materials) and the International Building Code (IBC), which both recommend and require testing of various materials. There are separate testing requirements and definitions for combustibility and conductivity provided by the National Institute of Standards and Technology (NIST). The regulations that affect biodegradability, recycled content, and reclaimed content are also relevant to Ecovative’s mission. A brief analysis of Leadership in Energy and Environmental Design (LEED) was provided within the context of Ecovative’s role in green building projects, and an examination of additional organizations administering standards and certifications was provided for consideration.

Pathways such as strategic planning, market selection, technological/research, and commercialization were discussed. With regard to the markets determined most relevant to Ecovative’s products an overview of the markets, major trends driving each market, and operations of the largest participants in each market were provided. 

SiMPore Technology: Ultra SM 
SiMPore, Inc.

SiMPore, Inc. licensed a new silicon membrane technology from the University of Rochester for the separation and purification of biomolecules and other nano-size particles in a wide range of applications. The technology provided for substantial price and efficiency improvements over filters that were then on the market. The report described the improvements in the filter technology, and contrasted it with similar technologies of competitors and potential partners. The markets for protein separation, virus filtration, and dialysis were considered, and an overview of the dominant technologies, market size, trends, and prominent market participants was provided. The process for including SiMPore’s nanofilter in new and existing medical devices was described, including an analysis of the complex and extended Food and Drug Administration (FDA) approval process required prior to utilizing new medical devices in the United States. SiMPore’s University relationships, including the company’s licensing agreement with the University of Rochester, were considered. Relevant tax laws and a discussion of the tax implications that can flow from research conducted in tax exempt facilities was discussed. Finally, potential market applications, risks, costs, returns, and suggestions for the development of SiMPore’s business were provided. 

DeaD Assay and Identified Compounds
Client: The University of Rochester Office of Technology Transfer

This report focused on two technologies developed by researchers at the University of Rochester; namely the DeaD assay and the compounds discovered through the assay’s unique screening process. The report analyzed several of the key competitors’ strategies within their respective, somewhat overlapping, markets. The primary markets surveyed were: Parkinson’s, Alzheimer’s, Type II Diabetes, cancer, Macular Degeneration, and dermatology. Related to these markets is the derived intellectual property (IP) from age-related disease research. The report assessed several disclosed assays and compounds by drawing similarities and highlighting deviations of the DeaD assay and compounds to those currently patented. The IP section provided information related to licensing research tools such as: reach through royalties, exclusive licenses and patent exhaustion. Associated with the IP section was an overview of National Institutes of Health (NIH) and Bayh-Dole regulations relevant to the University of Rochester’s decisions regarding its technology The FDA approval process was provided in order for the University of Rochester to fully consider the option of continuing research through clinical trials and ultimately carrying its compounds to market. Information regarding business models, such as direct market entry as a “start-up,” partnering, outright sale, initial public offering and venture capital was included. An overview of the competitive landscape of both the assay and compound market and the likely challenges of entrance into the pharmaceutical and biotechnology industry was provided. The report concluded with recommendations regarding the DeaD Assay and compounds developed based cumulatively on the competitive landscape, available business model alternatives, licensing opportunities, and current competitor intellectual property. 

University - Industry Sponsored Research Contract Term Analysis

This research report provides both academic institutions and private industry with information relevant to the efficient negotiation of reasonable and mutually beneficial sponsored research agreement terms. It seeks to reduce the amount of time negotiating agreements which delays and even precludes research collaborations between academic institutions and private industry.

The research team surveyed various private industries to identify practices that facilitate contract negotiation with respect to typically contentious issues. The report analyzes the surveys completed by companies in order to identify practices that facilitate contract negotiation between academic institutions and private industry with respect to typically contentious issues.

State Intellectual Property Policies

This report discusses the role of state government in creating an atmosphere where University research and development can flourish and where the state can benefit from its investment in research. Research has been compiled to provide a potential resource for policy makers who are considering a comprehensive statewide intellectual property (“IP”) policy.

The report discusses the current environment of university IP commercialization. It reviews federal IP policies and industry push-back on university R&D. Information is provided concerning university technology transfer activities and factors from within and outside the University that affect local economic development. Data is provided showing total university IP expenditures, invention disclosures, filed patent applications, issued patents, start-up formations, license income, and finally, licenses and options executed.

The report summarizes the findings, guiding principles, objectives and recommendations from a California report written for policy makers who are considering a comprehensive state IP policy. It reviews current New York agencies’ IP policies, including SUNY, the Research Foundation, NYS College of Agriculture and Life Sciences at Cornell University, CUNY and the CUNY Research Foundation, NYSTAR, and NYSERDA. The report discusses current New York Assembly activity with regard to a comprehensive state IP policy.

Finally, the IP policies of all fifty states in the US are canvassed, presenting their respective state policies, summaries of their university system IP policies and other relevant specialized funding agencies.

Eastman Kodak Company: GEMS Technology 
Eastman Kodak Company

Kodak developed a technology comprised of a microelectromechanical systems (MEMS) device that can be used to modulate light. The technology can be employed in a variety of applications, such as electronic displays. The report included a technological overview of the device as well as a brief description of several competing display technologies. Potential markets were researched including consumer home display, gaming, medical image display, computer-aided design workstations, commercial motion picture theatres, advertising, 3-D projection and other stereoscopic technologies, and printing markets. A patent search for patents assigned to competitors or potential partners was executed. An overview of the governmental agencies and laws regulating lasers, laser products and radiation emitting products was provided. Finally, an analysis of the research and recommendations regarding commercialization, prospective market entry and licensing ventures involving the technology were provided. 

Overview of MEMS-Based Sensor Organizations Inside and Outside New York State 

Infotonics develops and prototypes microsystem concepts including design, microfabrication and device packaging. It provides support to facilitate microsystem commercialization. This report focused on MEMS technology that can be used to assist in detection and prevention of terrorist acts, including biological and chemical agents, explosives, and nuclear weapons. The report reviewed major types of terrorist threats and the sensor technology currently being explored and researched for addressing the threats. An overview of businesses, universities, laboratories and fabrication facilities currently engaged in MEMS-based sensor technology research was provided. Information about intellectual property and patents held by some of the organizations reviewed was outlined. Potential partnering opportunities based on the patent landscape were identified and analyzed.

High Efficiency Linear Power Amplifier
Anaren Inc.

This project focused on a technological innovation which would create a dramatically increased efficiency helpful to the functioning of cellular telephone base stations. The project reviewed the wireless industry, and how the new technology was relevant to the industry. It described the key players in the market sectors relating to the Client's proposed application. It provided extensive patent analysis of patents relevant to the proposed application and discussed various commercialization strategies including specific recommendations as to preferred approaches to commercialization.

Sialic acid and N-acyl sialic acid analog production by fermentation of metabolically and genetically engineered Escheriachia coli

Dr. Christopher Boddy, Syracuse University

This project analyzed applications for a new method of producing sialic acid. The report provided an overview of the physiological and pathological functions of sialic acid as well as its potential alternative applications. The report estimated the value of the intellectual property using the patented Competitive Advantage Valuation (CAV) method. CAV is a valuation method that takes into account the main determinants of technology values, and applies a combination of disaggregation and income valuation approaches to yield results. The development and commercialization analysis discussed strategies for pursuing future opportunities for the production and use of sialic acid, including a discussion of potential commercialization, licensing ventures, and prospective market entry. The report concluded with recommendations for future development and commercialization of the technology.

Welch Allyn Communications Protocol
Client: Welch Allyn, Inc.

This project focused on options for introducing a universal communications protocol into the medical device market. It explored different markets as potential applications for the protocol, and made recommendations accordingly. It analyzed the technology, performed a business analysis, and provided case studies to illustrate relevant experiences of similar products. A legal and regulatory overview of consortia, FDA, HIPAA and anti-trust issues was provided. Finally, possible business models were discussed.

Composite material manufacturing
Client: Composite Factory, Inc.

This project focused on making recommendations regarding market applications for a fiber composite material manufacturing company. It explored the process technology behind fiber composite products, and included an analysis of the relevant market and partnering opportunities with academic institutions, an analysis of relevant intellectual property analysis, and a review of government programs that might be of assistance to the Client's mission. Finally, recommendations for successful commercialization of a specific fiber composite product were made. 

Advanced Biological Wound Dressing
SUNY Stony Brook Center for Biotechnology

This project focused on a technology that could significantly improve the healing of chronic wounds. The technology utilizes a provisional extracellular matrix ("SmartMatrix") to deliver fibronectin to the wound site, thereby encouraging fibroblast migration, a critical step in wound healing. The research compared SmartMatrix to other wound healing technologies, considered the market size and structure for chronic wound healing products, reviewed the patent protection for SmartMatrix and alternative technologies, described the FDA approval process for medical devices, and assessed the value of SmartMatrix technology for purposes of seed investment. The research also analyzed alternative business models for a start-up company to commercialize SmartMatrix technology.

Photonic Biopsy Pill
Infotonics New York State Center of Excellence

This project focused on technologies being developed by the City University of New York's Center for Photonic Applications. The research compared biopsy technology that utilizes photonics and spectral imaging with alternative technology platforms that utilize optical imaging and chemical detection. The report reviewed the market for biopsy pills and focused on detection of cancer in the upper digestive tract. In addition, the report reviewed the foundational science of photonic light emission and spectral imaging. The report concluded by considering which component parts are necessary for a photonic biopsy pill, which of these parts are available off-the-shelf, and which of these parts would require customized research and development.

Biologue Continuous Glucose Monitoring System
Rensselaer Polytechnic Institute Center for Automation Technologies

This project was undertaken on behalf of a start-up company with core patents covering an implantable glucose measuring device, a wireless signal transmitter, and a signal receiver and analyzer. The report discusses how the Biologue Continuous Glucose Monitoring ("CGM") system works and how it compares to alternative glucose monitoring technologies. The market section of the report provides information on the companies and products in the diabetes device market, and the regulation section provides information on FDA medical device regulation and the experimental use exemption to patent infringement under the Hatch-Waxman Act. The concluding sections of the report analyze the potential value of the Biologue CGM for seed investment and suggest alternative business models and commercialization strategies for bringing the Biologue technology to market.

University-Industry Sponsored Research - Opportunities and Obstacles
Clients: Eastman Kodak, ITT Space Systems, Corning, University of Rochester and Rochester Institute of Technology

This project was undertaken over two semesters. During the first semester, the research team studied the sponsored research web pages for 19 universities to determine universities' preferred contract terms and policies. When possible, the research team also interviewed sponsored research officials to confirm or clarify information from the web pages. The research focused on eight key issues in sponsored research agreements - equipment ownership, contract termination, confidentiality, ownership of discoveries, warranties and limitations of liability, publication, indemnification, and licensing. During the second semester, the research team surveyed a group of companies from different industries and of different sizes to determine their contract preferences and policies on these same key issues. The final report will be published by the New York State Office of Science, Technology and Academic Research.

Natural Language Processing Technology for Analysis of Medical Records
Columbia University Center for Advanced Information Management

This project reviewed the state-of-the-art in natural language processing (NLP) as applied to medical records, the Columbia University NLP medical record technology (MedLEE), FDA requirements for validation of medical device software and approval of MedLEE by software standards committees. The project also considered the pros and cons of commercializing MedLEE technology through a spin-off company or through licensing; and, in the case of licensing, the market segments in which the MedLEE would have the highest valued applications. The report concluded with a valuation of MedLEE technology and suggestions for commercialization strategies.

Intellectual Property Management Practices in Complex Research Environments
Rochester Institute of Technology Center for Integrated Manufacturing Studies

This research project analyzed the creation, protection and management of intellectual property in complex research environments that include faculty, students, industry funding and industry researchers, and government funding and government researchers. The report suggested six best practices for intellectual property management and ten specific steps to achieve these best practices. To maximize the capture of intellectual property, the report suggested reporting form templates, procedures and timetables.

DNA Computer Sensor Technology
Royal Philips Electronics

This project explored a futuristic in vivo medical diagnostic technology capable of detecting genetic markers associated with particular diseases, and, in the event that genetic markers are detected, releasing drugs to treat the diseases. The report included information on alternative non-invasive and invasive diagnostic and therapeutic procedures, gene therapy technologies, the FDA regulation of medical devices and the companies and research centers most actively engaged in DNA diagnostic and therapeutic research. The report also included an analysis of the principal DNA diagnostic and delivery patents.

Six Degrees of Freedom Sensor Market Applications
Lawrence Livermore National Laboratory

This project studied a novel non-contact sensor technology (Six DOF sensor) that is able to determine both the position of an object in the x, y and z axes and the rotation of the object around each of these axes with micron-level accuracy. The Six DOF sensor is lightweight, small and inexpensive. The research project included a technical comparison of the Six DOF sensor to sensors currently being used, and research on five potential applications: industrial automation, aviation quality control, remote surgery, medical rehabilitation, and augmented and virtual environments. The size, structure, consumers and suppliers for each of these markets were reviewed, The report concluded with suggestions for various forms of partnership arrangements with firms in each of these markets.

Orthoswitch Technology
OrthoSystems, Inc.

This project was undertaken on behalf of a start-up company with multiple issued and pending patents. It focused on a technology for the detection of waterborne pathogens such as Cryptosporidium and Giardia and toxins such as ricin. The Orthoswitch technology is an aptamer-based detection technology capable of performing real-time continuous detection of toxins and microbial pathogens in water systems. The report compared the Orthoswitch technology to alternative technologies, reviewed the involuntary and voluntary water testing markets, provided an in-depth analysis of the EPA's water testing regulations and their potential to create new market opportunities, and concluded with a discussion of possible strategic alliances that could be formed in different market segments.

Physician Office Ultrasonic Imaging
Welch Allyn, Inc.

This project was undertaken on behalf of a major medical device manufacturing company. The research analyzed the prospect of a hand-held, inexpensive ultrasound device available for primary care physicians. The report reviewed the basic science underlying ultrasound technology, the growth and driving forces in the ultrasound market, the factors that would influence the purchase of ultrasound equipment by primary care physicians, and the legal and insurance concerns that might affect primary care physicians' willingness and ability to utilize ultrasound technology. It also reviewed the universities with active research programs in the field of ultrasound technology and identified potential licensing partners based on their core competencies, patent portfolios and corporate profiles.

Displacement Flow Immunoassay Technology.
Naval Research Laboratory

This project focused on a novel immunoassay technology (DFI) that is rapid and highly sensitive, and does not require incubation steps or the use of additional reagents. The final report discusses the basic operation of the DFI technology and the series of patents that have been issued on DFI technology. The report then considers four potential applications of the DFI technology - monitoring food safety and purity, monitoring administration of therapeutic drugs, detection of explosives and detection of air-borne pathogens. The report reviews the regulation of pesticides, herbicides, organic foods and organic food programs, and concludes that the DFI technology could be especially valuable in agricultural applications. The report also included suggestions on ways to introduce DFI technology into these high-value agricultural markets.

Conversion of PDF Files to SGML/XML Formats

This report was undertaken for a start-up company in a local business incubator. The technology studied in the report consists of a set of document conversion tools that can be used to facilitate the processing of legacy paper and electronic documents into industry standard SGML/XML formats. The report reviews competing approaches to document conversion and the military and commercial document conversion markets. Because the client company was involved in subcontract work for a large defense contractor, the report provided considerable information on the protection of trade secrets and non-disclosure agreements. The report also explains the general requirements for patenting software algorithms.